Ingredient Spotlight: Peppermint – Isagenix Health

Peppermint is a perennial herb — meaning it lives more than two years — native to Europe and Asia, naturalized in the northern U.S. and Canada, and now cultivated in many parts of the world. The herb is best known for its flavor and fragrance. Peppermint leaves, both fresh and dried, and peppermint essential oil are used in many food, cosmetic, and pharmaceutical products, including confectionaries, chewing gum, toothpaste, and medicine.

Origin and Botany of Peppermint

Despite its widespread use and various applications, peppermint is not an ancient herb and does not breed true from the seed. The plant originated in 1696 in England as a natural hybrid of two herbs in the Lamiaceae family, spearmint (Mentha spicata L.) and water mint (Mentha aquatica L.). Peppermint’s scientific name is Mentha x piperita L. The herb has stalked, smooth, dark green leaves and blunt, oblong clusters of pinkish-lavender flowers (1, 2, 16).

Peppermint Essential Oil Health Benefits and Clinical Studies

Peppermint has multiple uses and health benefits. It’s a good antioxidant, antiseptic, and nutritional and digestive aid. It may help with swelling and pain when applied topically (1, 2, 3, 5, 6, 7, 14). Peppermint oil has the peculiar ability to change sensation on the skin and oral mucosa (inside of the mouth), which can soothe the gastrointestinal and respiratory tract (1, 2, 5, 9, 15).

Clinical trials have shown that peppermint oil has great promise when it comes to treating hard-to-manage digestive issues (2, 9, 15). More than 10 clinical trials have been conducted to appraise the oil’s effects. Nine studies evaluated 726 patients who met specific scientific inclusion criteria. Five trials appraised the effectiveness of equivalent doses of peppermint oil within different application regimens. Among these studies, five randomized, placebo-controlled trials showed a global improvement in digestive symptoms after using peppermint oil. Altogether, the studies concluded that peppermint oil was significantly superior to a placebo for global improvement of digestive symptoms (2, 9, 15).

Peppermint oil also enhanced memory and increases alertness following inhalation in healthy male and female subjects (10). Furthermore, a mixture of essential oils including peppermint reduced perceived mental exhaustion and moderate burnout in a small pilot study (11). Enhanced attention and performance on visual vigilance tasks have also been noted with peppermint aroma (1). Externally, the oil was found useful for helping with mental clarity (1, 2).

The Chemistry of Menthol, The Main Chemical in Peppermint Oil

Chemicals found naturally in the peppermint plant include phenols and fragrant terpenes, especially in the leaves. Terpenes are selectively extracted for essential oil via steam distillation from fresh leaves. Peppermint oil’s main volatile constituent, comprising 33 to 60 percent of the oil, is menthol, a substance long used as a soothing balm. When applied topically in the oral mucous membrane, menthol alleviates minor throat soreness and mouth irritation caused by canker sores.

Menthol also activates the cold receptors on the skin, producing a chilling effect when taken orally or applied topically. It does not actually modify the temperature of the skin, but merely generates the feeling of temperature change. Other volatile components of peppermint oil include:

  • Menthone: 15-32 percent.
  • Isomenthone: 2-8 percent.
  • 1,8-cineole (eucalyptol): 5-13 percent.
  • Menthyl acetate: 2-11 percent.
  • Menthofuran: 1-10 percent.
  • Limonene: 1-7 percent (12).

The phenolic constituents of peppermint leaves include rosmarinic acid (present in rosemary) and several flavonoids, including eriocitrin, luteolin, and hesperidin, which have recognized antioxidant and cellular protection effects (12). Luteolin is a well-known flavone that helps support cardiovascular health and provides other nutritional benefits (16).

Peppermint: Naturally Uplifting and Cooling

In conclusion, peppermint provides good nutritional support due to its digestive, antiseptic, and sensory effects. It also has soothing properties, possibly due to modulation of cytokine production. Dietary intake of peppermint can affect the gut microbiome and support gut comfort (15). Peppermint oil may be the right solution for those seeking a naturally uplifting yet calming effect, improved digestion, or a post-workout cooling sensation.


  1. McKay DL, Blumberg JB. A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). Phytother Res. 2006 Aug;20(8):619-33.
  2. Aetheroleum Menthae Piperitae, In WHO monographs on selected medicinal plants, Vol 2, World Health Organization, Geneva, Switzerland; 1999.
  3. Zheng W, Wang SY. Antioxidant activity and phenolic compounds in selected herbs. J Agric Food Chem. 2001;49(11):5165-70.
  4. Inoue T, Sugimoto Y, Masuda H, Kamei C. Antiallergic effect of flavonoid glycosides obtained from Mentha piperita L. Biol Pharm Bull. 2002;25(2):256-9.
  5. Iscan G, Kirimer N, Kurkcuoglu M, Husnu Can Baser K, Demirci F. Antimicrobial screening of Mentha piperita essential oils. J Agric Food Chem. 2002;50(14):3943-6.
  6. Mahmood SA, Abbas NA, Rojas RL. Effects of aqueous extracts of peppermint, fennel, dill and cumin on isolated rabbit duodenum. U Aden J Nat Appl Sci. 2003;7:377–383.
  7. Arakawa T, Shibata M, Hosomi K et al. Anti-allergic effects of peppermint oil, chicle and jelutong. Shokuhin Eiseigaku Zasshi. 1992;33:569–575.
  8. Atta AH, Alkofahi A. Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. J Ethnopharmacol. 1998;60(2):117-24.
  9. Khanna R, MacDonald JK, Levesque BG. Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis. J Clin Gastroenterol. 2014;48(6):505-12.
  10. Moss M, Hewitt S, Moss L, Wesnes K. Modulation of cognitive performance and mood by aromas of peppermint and ylang-ylang. Int J Neurosci. 2008;118(1):59-77.
  11. Varney E, Buckle J. Effect of inhaled essential oils on mental exhaustion and moderate burnout: a small pilot study. J Altern Complement Med. 2013;19(1):69-71.
  12. Grigoleit HG, Grigoleit P. Pharmacology and preclinical pharmacokinetics of peppermint oil. Phytomed. 2005;12(8):612-6.
  13. Khan IA, Abourashed EA. Leung’s Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. Third edition, John Wiley & Sons, Inc., New York, 2010.
  14. Shams R, Oldfield EC, Copare J, Johnson DA. Peppermint Oil: Clinical Uses in the Treatment of Gastrointestinal Diseases. JSM Gastroenterol Hepatol 3025, 3(1): 1036.
  15. Foster S, Tyler VE. Tyler’s Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies, 4th Edition. New York: Haworth Press; 1999.

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Ingredient Spotlight: Apple Cider Vinegar

Isagenix offers weight loss solutions and aids to limit calorie intake. One of these is Isagenix Natural Accelerator™, a formula combining ingredients for blood sugar support and thermogenesis like acetic acid, which comes from apple cider vinegar.

Vinegar is a liquid food product that has been used in human households for more than 10,000 years (1). While vinegar shares some similarities with wine and yogurt, those foods are byproducts of bacterial fermentation, whereas vinegar is made when microorganisms produce acetic acid. Vinegar contains about 5 to 20 percent acetic acid, water, and trace amounts of compounds from the food source (1, 2, 3). Today, the most common vinegars on the market are apple cider vinegar and normal vinegar (3).

Several animal and clinical studies since 1998 demonstrate that vinegar’s most significant health benefits are modulating blood sugar and improving sensitivity to the hormone insulin so cells can absorb sugar (3-6). Vinegar’s blood sugar modulating effects are most likely due to the presence of acetic acid (3-8). Studies show that acetic acid helps to inhibit carbohydrate-specific digestive enzymes, such as amylase, slowing down the breakdown and absorption of sugars and starches and reducing their impact on blood sugar. An additional effect is a feeling of fullness, which may help support weight control, especially in overweight or obese individuals (3-7).

A Liquid Appreciated by Ancient Cultures Derived From Wine

“Vinegar” comes from the French word “vinaigre,” which means “sour wine.” If wine is left open to the air, it rapidly becomes acidic, turning sour (1). Thus, the origin of vinegar is closely associated with wine’s discovery.

Vinegar has been available in households for over 10,000 years (3). Around 5000 B.C., Babylonians used it as a food, preservative, and pickling agent (1). Vinegar residue has been found in Egyptian urns dating back to 3000 B.C. In China, texts about vinegar were written as long ago as 1200 B.C. (2).

Several ancient societies touted vinegar for its health properties. Hippocrates, the father of medicine, recommended cider vinegar mixed with honey as a health aid. Diluted vinegar was often used as a vitalizing and energizing tonic. Roman soldiers used a refreshing vinegar-based beverage called “posca” to clean and disinfect wounds (2).

Apple cider vinegar is one of the most common vinegars still in use today. It’s made from fruit juices, grapes, dates, figs, sugar cane, and apples (3). In modern scientific literature, researchers have reported that vinegar has an effect on sugar and lipid modulation (3-7).

Acetic Acid: The Main Compound in Vinegar

For a long time, we only had anecdotal evidence that vinegar can assist in weight loss diets. Eventually, animal and randomized, placebo-controlled clinical studies were designed to understand if consuming vinegar before or after a meal had any effect on weight loss and sugar levels (3).

In 1998, a seminal animal study demonstrated that when given a solution of 2 percent acetic acid after a high-glucose meal, rats’ blood glucose levels were reduced (3). This led to a number of clinical trials that have replicated this finding (3, 4, 5, 6).

Researchers have since hypothesized that vinegar’s blood sugar modulating effects are related to acetic acid (4, 5). Acetic acid appears to control carbohydrate digestion by inhibiting the enzymes responsible for breaking down table sugar and other disaccharides in our food (5). The effect appears to be exclusive to acetic acid and other organic acids (e.g., citric, succinic, malic, and lactic) while having negligible effects on disaccharides’ activity (5).

Effects of Vinegar Found in Clinical Studies

Several randomized, crossover, placebo-controlled clinical trials have been conducted to confirm earlier studies’ results supporting vinegar’s ability to lower postprandial glucose and improve insulin sensitivity (3-7).

Carol Johnston, a registered dietitian and professor at the School of Nutrition and Health Promotion at Arizona State University, has been involved in several of the early studies about vinegar. Her findings suggest that in healthy subjects, vinegar moderately reduces glucose response after high-glucose meals. The reduction in fasting glucose and the decrease in blood glucose after high-carbohydrate meals increase insulin response and satiety (3-5).

In Japan, Kondo et al. studied 155 obese and healthy subjects who consumed a 500 mL beverage with 15 to 30 mL (1 to 2 tablespoons) apple cider vinegar for 12 weeks (7). They found that body mass index, visceral fat, and waist-to-hip ratio all decreased at both doses used (7).

A systematic review of randomized and nonrandomized controlled clinical trials on diabetic individuals who consumed 4 teaspoons to 2 tablespoons of vinegar found a small but significant reduction in mean HbA1c after eight to 12 weeks of vinegar administration (3).

Although these results appear to be unusually impressive, apple cider vinegar isn’t sufficient on its own for blood sugar management, especially in individuals with reduced insulin sensitivity. However, apple cider vinegar taken daily — by the spoonful or in supplements like Natural Accelerator — may be useful while on a weight loss plan by helping to manage appetite and blood sugar.


  1. Bourgeois JF, Barja F, The history of vinegar and of its acetification systems. Arch Sci 2009;62:147-160.
  2. Solieri L, Giudici P, Vinegars of the world, Springer-Verlag, Italy, 2009.
  3. Fahey R Health Benefits of Apple Cider Vinegar and Other Common Vinegars: A Review, Integrat Med Alert, 2017;20(6):1-8.
  4. Johnston CS, Steplewska I, Long CA, et al. Examination of the antiglycemic properties of vinegar in healthy adults. Ann Nutr Metab 2010;56:74-79.
  5. Johnston CS, Quagliano S, White S, Vinegar ingestion at mealtime reduced fasting blood glucose concentrations in healthy adults at risk for type 2 diabetes,  J Funct Foods 2013: 2007-2011.
  6. NewsRx. Reports from Shaheed Beheshti University of Medical Sciences Highlight Recent Findings in Obesity (Beneficial effects of Apple Cider Vinegar on weight management, Visceral Adiposity Index and lipid profile in overweight or obese subjects …) Obesity, Fitness & Wellness Week. (May 12, 2018): 6319.
  7. Kondo T, Kishi M, Fushimi T, et al. Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects. Biosci Biotechnol Biochem 2009;73:1837-1843.
  8. Ley SH, Hamdy 0, Mohan V, Hu FB, Prevention and management of type 2 diabetes: dietary components and nutritional strategies, The Lancet 2014;383(9933):1999-2007.

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Cleanse for Life: An Ingredient Breakdown

What’s your favorite Cleanse for Life® ingredient? For some, it might be aloe gel or peppermint for their digestive-soothing benefits, B vitamins for metabolism support, or turmeric and ashwagandha for their help with natural detoxification.

Because of its ingredient composition, Cleanse for Life is a versatile product that provides a variety of benefits depending on how you consume it. When taken each morning or at nighttime, it provides daily antioxidant protection. For those seeking weight loss or detoxification support, it’s a fundamental component of Cleanse Days. With Cleanse for Life’s demonstrated benefits in mind, its ingredients are worthy of a closer look.

Nourishing B Vitamins

Among the B vitamins in Cleanse for Life are niacin, vitamin B6, and vitamin B12. These vitamins are essential nutrients because of their roles in normal metabolism of proteins, fats, and carbohydrates and converting food into energy.

However, they also play a role in supporting the body’s normal antioxidant and detoxification systems. Niacin and B6, for example, are essential for the regeneration of cellular antioxidant and detoxification components (1). Vitamin B12 is also involved in the detoxification of homocysteine to help maintain cardiovascular health (2).

Choline and inositol, also ingredients in Cleanse for Life, are closely related to B vitamins and function by supporting normal metabolic and liver function (3, 4).

Biologically Active Botanicals

Cleanse for Life also features a variety of botanical ingredients with benefits that range from soothing the digestive system to providing detoxification support. Working in synergy, the combination of these ingredients is designed for proper nourishment on Cleanse Days as well as for daily use.

Aloe vera inner-leaf gel is an ingredient that shouldn’t be confused with aloe latex found in the outer part of the plant and known for being a laxative (5). In fact, the gel used in Cleanse for Life is charcoal processed to ensure no trace of any laxative component from aloe latex remain. The gel itself, however, contains polysaccharides associated with digestive support and in improving nutrient bioavailability (6,7).

Turmeric is another Cleanse for Life ingredient that contains a wide number of phytochemicals, but the primary component that’s attracted worldwide scientific inquiry is curcumin (8-10). Curcumin’s influence on metabolic pathways are numerous and complex. These include supporting detoxification, decreasing markers of oxidative stress in overweight and middle-aged adults, and supporting blood vessels and lipid metabolism, effects that contribute to brain and cardiovascular health (8-10).

Ashwagandha, an ancient Ayurvedic herb, is an adaptogen with many traditional and modern uses. Its chief biologically active components are withanolides found in the plant’s roots (11, 12). Eleuthero and rhodiola, also traditional adaptogenic herbs, are used in Russia and Scandinavia to strengthen the body’s resistance to stress and improve energy levels (12, 13). Scientific evidence suggests that the phytochemicals in these adaptogens work as key mediators in helping the body maintain homeostasis during stress (12, 13). Through this mechanism adaptogens also offer beneficial effects on the immune system and mental health.

Functional Flavors and Colors

Bilberry, raspberry, and purple carrot are notable for imparting color and flavor while also providing a source of polyphenols, most prominently, anthocyanins (14, 15). These anthocyanins have been investigated scientifically for a variety of positive effects on metabolic processes particularly in middle-aged and overweight adults (15).

Peppermint and fennel also add hints of flavor while, along with suma (or Brazilian ginseng), also providing soothing support for the gastrointestinal tract (16, 17). In combination with aloe gel, these ingredients make Cleanse for Life helpful for supporting gut health during all-day use on Cleanse Days.

The Science of Synergy

Collectively, these ingredients as components of Cleanse for Life demonstrated significant antioxidant protection while promoting the expression of key detoxification enzymes in a cellular model of oxidative stress and toxicity (18). The cells in the study not only lived longer but also exhibited signs of thriving with less signs of cellular stress (18).

Moreover, the use of Cleanse for Life and IsaLean® Shake was further studied in research that evaluated the release of toxins into the bloodstream during a weight loss regimen (19). The study found that nourishment from the products on Cleanse Days and Shake Days was associated with a concomitant reduction of oxidative stress and improved antioxidant status (19).

Getting to know each of Cleanse for Life’s ingredients can help guide how to best to use the product, such as whether to consume it daily or as part of Cleanse Days. It can also provide you a better understanding of why Cleanse for Life is one of the most original and popular Isagenix products.


  1. Agledal L, Niere M, Ziegler M. The phosphate makes a difference: cellular functions of NADP. Redox Rep. 2010;15(1):2-10.
  2. Huang T, Chen Y, Yang B, Yang J, Wahlqvist ML, Li D. Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality. Clin Nutr. 2012;31(4):448-454.
  3. Zeisel SH, Blusztajn JK. Choline and human nutrition. Annu Rev Nutr. 1994;14:269-296. (PubMed)
  4. Rolo AP, Teodoro JS, Palmeira CM. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. Free Radic Biol Med. 2012;52(1):59-69.
  5. Upton R, Axentiev P, Swisher MA. Aloe vera leaf, aloe vera leaf juice, aloe vera inner leaf juice, Aloe vera (L.) Burm. f. Standards of Identity, Analysis, and Quality Control, American Herbal Pharmacopoeia, 2012.
  6. Zhang Y, Liu W, Liu D, Zhao T, Tian H. Efficacy of aloe vera supplementation on prediabetes and early non-treated diabetic patients: a systematic review and meta-analysis of randomized controlled trials. Nutrients. June 23, 2016;8(7).
  7. Vinson JA, Al Kharrat H, Andreoli L. Effect of Aloe vera preparations on the human bioavailability of vitamins C and E. Phytomedicine. 2005;12:760–5.
  8. DiSilvestro RA, Joseph E, Zhao S et al. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J2012;11:79, 2012.
  9. Panahi Y, Hosseini MS, Khalili N et al. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial. Biomed Pharmacother 2016;82:578-82.
  10. Cole GM, Teter B, Frautschy SA. Neuroprotective effects of curcumin. Adv Exp Med Biol2007;595:197-212.
  11. White P.T., Subramanian C., Motiwala H.F., Cohen M.S. (2016) Natural Withanolides in the Treatment of Chronic Diseases. In: Gupta S., Prasad S., Aggarwal B. (eds) Anti-inflammatory nutraceuticals and chronic diseases. Advances in Experimental Medicine and Biology, vol 928.
  12. Panossian A, Wikman G. Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stree-protective activity. Pharmaceuticals 2010; 3: 188-224.
  13. Darbinyan V, Kteyan A, Panossian A, et al. Rhodiola rosea in stress induced fatigue–a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 2000;7:365-71.
  14. Manganaris, GA., Berry antioxidants: small fruits providing large benefits. J Sci Food Agric 2014; 94: 825–833.
  15. Olejnik A, Rychlik J, Kidoń, M., et al. Antioxidant effects of gastrointestinal digested purple carrot extract on the human cells of colonic mucosa, Food Chem, 2016, 190:1069-1077.
  16. Valussi M. Functional foods with digestion-enhancing properties. Int J Food Sci Nutr. 2012; Mar;63 Suppl 1:82-9.
  17. Costa CARA, Quaglio AEV, Di Stasi LC. Pfaffia paniculata (Brazilian ginseng) extract modulates Mapk and mucin pathways in intestinal inflammation, Ethnopharmacol, 2018; 213: 21-25.
  18. Gumpricht E, Kumar R, Hussain A, et al. A Natural Herbal Beverage Exhibits Significant Cytoprotection and Promotes Nrf-2 Activation in Cells April 2015 FASEB J 2015;29 (Supplement) Abstract #607.1.
  19. He F, Zuo L, Ward E, Arciero PJ. Serum Polychlorinated Biphenyls Increase and Oxidative Stress Decreases with a Protein-Pacing Caloric Restriction Diet in Obese Men and Women. Int. J. Environ. Res. Public Health 2017, 14, 59.

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Isagenix Pumpkin Shake Recipe (Periscope Broadcast)

Here is my special recipe for an Isagenix Pumpkin Shake. Please don’t think I am crazy and talking to myself! This video was a scope done on Periscope. Please follow me on Periscope @zumbamichelle25.

Ingredient Spotlight: Wolfberry – Isagenix Health

Although first described 2,000 years ago, the use of wolfberry in Traditional Chinese Medicine (TCM) formulas was revived at the end of the Empire of the Great Ming (1368–1644). The benefits of wolfberry to modulate stress and support faster post-exercise recovery have been confirmed by modern science, with water-soluble polysaccharides (LBPs) and other antioxidants in the fruit also managing free radicals to support healthy aging (1, 2, 3).

But what is wolfberry and goji berry, and why are there several species reported in the literature? “Wolfberry” and “goji berry” are synonyms (2). The plant genus Lycium, to which wolfberry belongs, has about 80 species distributed in Asia, South America, and southern Africa. Of seven species growing in China, the two species that are most commonly used interchangeably in TCM are L. barbarum and L. chinense, also known as gou qi or kei tze (2). L. barbarum has been the best studied.

The wolfberry fruit has been used in China for more than 2,000 years, and recorded in the Shen Nong Ben Cao Jing, the Divine Farmer’s Classic of Materia Medica, compiled in the first century CE (2, 3, 4). Wolfberry is one of the top 120 herbs in that book, believed to have remarkable health benefits and safety for strengthening the body, keeping it fit, prolonging life, and easing life through all the seasons (1, 2, 3, 4). Its reputation has extended to other traditional medicines in Asia, Taiwan, Japan, and Korea, where wolfberry is used for general debility (1, 2). Additional indications listed in authoritative books include supporting blood sugar control and visual health (1, 2).

Dried wolfberry fruit used in products has alkaloids, chlorogenic acid, carotenoids, amino acids, terpenes, vitamins, and polysaccharides. Some studies suggest the polysaccharides, extracted with hot water, are the main bioactive constituents (2, 3, 4). LBPs support general antioxidative effects and maintenance of blood sugar and lipid levels. For vision health, the carotenoid zeaxanthin is also required (1, 2). Human clinical trials focused on the effects of wolfberry and its polysaccharides on blood sugar and lipid levels, immune health, antioxidant effects, vision, weight management, general well-being, and as a tonic for fatigue and stress (2, 5, 6, 7, 8).

Positive Health Benefits of Wolfberry Polysaccharides

A prospective, randomized, double-blind controlled study of 67 individuals examined the effects of wolfberry polysaccharides on postprandial glucose and lipid levels. People were given either 300 mg of polysaccharides or placebo (2, 5). The group taking the polysaccharides experienced improved blood sugar and lipid support after intervention, compared to baseline (2, 5).

Several clinical studies demonstrated the positive effects of a daily serving of a L. barbarum supplement standardized to supply a polysaccharide equivalent of at least 150 g of fresh fruit on general health (6), as an immune modulator (7), on modulating antioxidant defenses (8), caloric expenditure, reducing fatigue after exercise (10), and, on weight control decreasing waist circumference in healthy overweight men and women (9). A tendency toward improved short-term memory and focus was found on older adults (55-72 years old). The study also confirmed that those who consumed wolfberry had supporting mental health and immunity benefits (6).

The study also demonstrated antioxidant effects through increases of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) along with a reduction of  markers of oxidative stress. These results suggest wolfberry protects against free radicals contributing to cardiovascular and brain health (2).

Wolfberry extracts, packed with polysaccharides, have also demonstrated they can increase thermogenesis, postprandial energy expenditure, and have positive effects on waist circumference and other weight assessment such as BMI, and total body fat (2, 9). Wolfberry showed benefits reducing fatigue and improving exercise performance, by increasing significantly VO2 max, a measure of the maximum volume of oxygen that an athlete can use (10). A study also suggests the consumption of wolfberry may provide adaptability to physical stressors (such as exercise) (2, 10).

The Safety of Wolfberry

No side effects have been reported in monographs and clinical trials at the amounts of wolfberry usually recommended (1, 6, 7, 8, 9, 10). The amount of wolfberry used in Isagenix products is within those reported in the literature, and therefore can be safely consumed.

Isagenix Ionix Supreme has the Power of Wolfberry

Isagenix offers Ionix® Supreme with the health benefits of water-soluble polysaccharides from wolfberry fruit. The number of polysaccharides in a serving of Ionix Supreme is within those reported in the literature, and therefore can be safely consumed. Ionix Supreme is individually adjusted, starting with half to one teaspoon a day based on what works best for you.

The Isagenix no-compromise quality standards include the use of carefully sourced raw materials that undergo stringent analytical testing procedures to detect the presence of contaminants such as pesticides, heavy metals, and microbes. Isagenix wolfberry fruit extract is made using a hot water extraction process, which replicates the traditional hot water brew preparation of traditional Asian medicines used for centuries around the world.


  1. Gruenwald J, Brendler T, and Jaenicke C. PDR for Herbal Medicines. Medical Economics Company, Inc. 2000. Montvale, NY.
  2. Engels G, Brinckmann J, Lycium (Goji Berry) Lycium barbarum and L. chinense Family: Solanaceae HerbalGram. 2017, 113: 8-18.
  3. Bucheli P, Gao Q, Redgwell R. Vidal K. Wang J. and Zhang W. Biomolecular and Clinical Aspects of Chinese Wolfberry In: Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition, Benzie IFF, Wachtel-Galor S, editors. CRC Press/Taylor & Francis, Boca Raton, 2011.
  4. Khan IA, Abourashed EA, Leung’s Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. Third edition, John Wiley & Sons, Inc., New York, 2010.
  5. Cai H LF, Zuo P, Huang G, et al. Practical application of antidiabetic efficacy of Lycium barbarum polysaccharide in patients with type 2 diabetes. Med. Chem. 2015;11:383-390.
  6. Amagase H, Nance DM. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (goji) juice, GoChi. J Altern Complement Med. 2008;14(4):403-412.
  7. Amagase H SB, Nance DM. Immunomodulatory effects of Lycium barbarum fruit juice in Chinese older healthy human subjects. J Med Food. 2009;12(5):1159-1165.
  8. Amagase H, Sun B, Borek C. Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults. Nutr Res. 2009;29(1):19-25.
  9. Amagase H, Nance DM. Lycium barbarum increases caloric expenditure and decreases waist circumference in healthy overweight men and women: pilot study. J Am Coll Nutr. 2011;30(5):304-309.
  10. Amagase H, Nance DM. Lycium barbarum fruit (goji) attenuates the adrenal steroid response to an exercise challenge and the feeling of tiredness: a randomized, double-blind, placebo-controlled human clinical study. J. Food Res. 2012;1(2).
  11. Cheng CY, Chung WY, Szeto YT, Benzie IFF. Fasting plasma zeaxanthin response to Fructus barbarum L. (wolfberry; kei tze) in a food-based human supplementation trial. Brit. J. Nutrit.. 2007;93(01):123.

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