Spotlight: Bacopa – Isagenix Health

Bacopa is an herb originally from India and a component of many ancient Ayurvedic formulations. Its use, dating back to 2,500 BC, includes a tonic formula to stimulate cognitive function and prolong longevity.

Numerous clinical studies have been conducted to evaluate bacopa’s benefits on brain health and cognitive function (1-8). Bacopa extracts have been clinically demonstrated to improve cognition, particularly speed of attention, in healthy individuals. Bacosides, key compounds present in bacopa, are being investigated for their neuroprotective effects and ability to modulate the brain neurotransmitters acetylcholine and serotonin (1, 7).

Nutritional Support for a Sharp Mind

Finding optimal nutritional support is a step in the right direction when it comes to preserving the brain health and memory of an aging population. Although several biomedical research groups are working on understanding brain function, designing a medicine for cognitive support has not yet been possible. Ancient practices have a different perspective and solution. For example, Indian Ayurvedic medicine has described alternative ways to combat mental fogginess and to slow down the brain’s aging process through a combination of herbs and energy balance.

An Ancient Nootropic Herb

Bacopa monnieri (L.) Wettst, is an ancient herb also known as thyme-leaved gratiola or brahmi (10, 11, 12). The plant is found in warm, marshy wetland areas, including India, East Asia, Australia, and the United States (11, 12, 13). Bacopa is a member of the plantain family, Plantaginaceae (4), a key ingredient in Ayurveda and Traditional Chinese Medicine (10, 12).

The ancient Ayurvedic books Caraka Samhita (2,500 B.C.), the Sushruta Samhita (2,300 B.C.) and the Indian Materia Medica, give account of bacopa’s many benefits as a tonic to support intellectual activity (10, 11). In modern scientific literature, bacopa is defined as a nootropic substance (11, 14, 15, 16, 17), from the Greek “nous” meaning “mind” and “trepein” meaning “to bend.” Nootropics improve cognitive function, particularly executive functions, memory, creativity, or motivation. This help protect the brain from chemical and physical assaults, and increases the efficacy of neuronal firing control mechanisms in cortical and sub-cortical regions of the brain.

Key Components Found in Bacopa

Researchers have found a unique chemical class of triterpenoid saponins, the bacosides, (16). Bacosides are unique to this plant’s genera and their content is used in the quality control of the herb (8). The physiological role that bacosides play in bacopa benefits is beginning to be understood (11, 16, 18). Bacoside A and bacoside B, steroidal compounds in nature, seem to be essential for the neuroprotective and neuromodulating effects of bacopa extracts (7).

Bacopa extract benefits are demonstrated in preclinical tests and clinical trials

Bacopa extracts have been reported to have many actions on in vitro and animal studies, protecting brain cells from oxidative stress and modulating the formation of essential brain chemicals (6, 16). Animals given bacopa extracts show benefits in motor learning, acquisition, retention, and delay extinction of newly acquired behaviors (16). Numerous clinical trials with bacopa have now been published (1-9).

Australia is the leading country on the clinical trials effort, conducting most recent randomized, double-blind, placebo-controlled studies under the supervision of Dr. Con Stough, director of the Swinburne Centre for Neuropsychology University in Melbourne and Director of the National Institute of Complementary Medicine (NICM) Collaborative Centre for the Study of Herbal and Natural Medicines for Neurocognition (2-6).

Australian clinical trials have shown bacopa benefits on human cognition and as a neuroprotective and memory enhancer (1-8). The combined results of these trials suggest bacopa works in complementary pathways in the brain providing an integral protection and neuromodulation, improving cognition (7). The mechanism of action of bacopa includes inhibition of free radicals responsible of causing harm to brain cells. It also works as both an inhibitor of acetylcholinesterase and as an activator of choline acetyltransferase, two key enzymes modulating brain’s activity (16, 18). The result is that the neurotransmitter acetylcholine is increased supporting a sharp memory and retention (16, 18).

Isagenix nutritional support with bacopa

Isagenix offers bacopa in both Ionix® Supreme and in IsaGenesis®, two key products providing optimal nutritional support to keep a healthy and active population with a sharp brain. These products provide different levels of bacopa extract aimed to help support your mental health.

References

  1. Stough C, Downey LA, Lloyd J, et al. Examining the nootropic effects of a special extract of Bacopa monniera [sic] on human cognitive functioning: 90 day double-blind placebo controlled randomized trial. Phytother Res. 2008;22:1629-1634.
  2. Benson S, Downey LA, Stough C, et al, An Acute, Double-Blind, Placebo-Controlled Cross-over Study of 320 mg and 640 mg Doses of Bacopa monnieri (CDRI 08) on Multitasking Stress Reactivity and Mood, Phytother Res. 2013; DOI: 10.1002/ptr.5029.
  3. Downey JK, Nemeh F, Lau A, et al, An Acute, Double-Blind, Placebo-controlled crossover study of 320 mg and 640 mg doses of a special extract of Bacopa monnieri (CDRI 08) on sustained cognitive performance, Phytother Res., 2013; 27: 1407–1413.
  4. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (sic) (Brahmi) on cognitive function in healthy human subjects. Psychopharm, 2001; 156: 481–484.
  5. Stough CK, Pase MP, Cropley V, et al. A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people: The Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910). Nutr J, 2012; 11: 1–9.
  6. Morgan AM, Stevens J, Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial, J Alternat Complement Med, 2010; 16: 753–759.
  7. Stough C, Scholey A, Cropley V, et al. Examining the cognitive effects of a special extract of Bacopa monniera (sic) (CDRI 08: KeenMind): A Review of Ten Years of Research at Swinburne University J Pharm Pharm Sci 2013;16(2): 254 – 258.
  8. Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, Limpeanchob N, Scholfield CN. Metaanalysis of randomized controlled trials on cognitive effects of Bacopa monnieri J Ethnopharmacol. 2014;151(1):528-535.
  9. Kean JD, Downey, LA, Stough C. A systematic review of the Ayurvedic medicinal herb Bacopa monnieri in child and adolescent populations, Complem Ther Med, 2016;29:56-62.
  10. Nadkarni KM, Nadkarni AK. Dr. K. M. Nadkarni’s Indian materia medica: with ayurvedic, unani-tibbi, siddha, allopathic, homeopathic, naturopathic & home remedies, app. & indexes. 3 ed. Bombay, India: Popular Book Depot; Popular Prakashan; 1982.
  11. Nemetcheck MD, Stierle AA, Stierle DB, Lurie DI. The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain, 2017, Ethnopharmacol. 2017;197:92–100.
  12. Williamson E. Bacopa monnieri In: Major Herbs of Ayurveda. Churchill Livingstone; 2002, 321-325.
  13. Tropicos, The Missouri Botanical Garden databse, Accessed Mar 22, 2017 at: http://www.tropicos.org/Name/29202063
  14. Russo A, Borrelli F. Bacopa monniera [sic], a reputed nootropic plant: an overview. 2005;12:305-317.
  15. McPhee GM, Downey LA, Noble A, Stough C. Cognitive training and Bacopa monnieri: Evidence for a combined intervention to alleviate age associated cognitive decline. Med Hypotheses. 2016;95:71-76
  16. Aguiar S, Borowski T. Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res 2013;16(4):313-326.
  17. Abascal K, Yarnell E. Bacopa for the brain: a smart addition to Western medicine. Altern Complement Ther. 2011;17(1):21-25.

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Why Nitrate-Rich Shots Work for Cardiovascular Fitness

Studies have consistently shown that using nitrate-rich vegetable concentrates or shots, such as AMPED™ NOx, can improve cardiovascular fitness and exercise performance.

Now a group of scientists from the Netherlands suggests that there’s an obvious reason for these performance benefits—we’re just not getting enough vegetables in our diets daily.

In a recent review paper, researchers pointed out that our main supply of dietary nitrates comes from either green leafy or root vegetables, yet most of us don’t receive enough to see benefits (1). “The proposed benefits of dietary nitrate supplementation may very well be observed because a healthy diet is not yet achieved in most people,” the authors reported. They reasoned that the reported benefits of nitrate supplementation are likely observed because habitual nitrate intake is so low.

Despite the accumulating evidence supporting the health benefits of consuming more vegetables, the actual vegetable intake remains well below the levels proposed in multiple dietary guidelines (2). In fact, the average intake levels of vegetables has declined markedly over the past 30 years worldwide (3).

The consumption of sufficient amounts of vegetables is a cornerstone of a healthy diet and has been shown to contribute to the prevention of chronic metabolic diseases (4). There are several different classes of biologically active compounds in vegetables that impart beneficial effects, including vitamins, trace minerals, and dietary fibers to name a few (4).  Some of the most healthful vegetables, including spinach, arugula, lettuce, and beetroot contain high levels of nitrate (5).

While not a replacement for vegetable intake, supplementation with dietary nitrate has some notable advantages. Dietary nitrate supplementation has become a popular area of research with several publications reporting benefits to the cardiovascular system (6). It has also been reported to enhance muscle efficiency and fatigue resistance in both healthy and unhealthy individuals (1).

Consuming nitrates from food or dietary supplements increase the bioavailability of nitric oxide (NO) in the blood stream. NO has multiple functions in the body that may influence health and performance, including the regulation of blood flow, muscle contractility, glucose and calcium homeostasis, and mitochondrial respiration and biogenesis (7-9

In comparison to synthetic versions of nitrates, such as nitrate salts, those found in vegetables such as beetroot juice, spinach, celery, and arugula are found to exceed the effects of the same dose of sodium nitrate (10). This effect could be attributed to the presence of various polyphenols and antioxidants found in vegetables (10).

Knowing that vegetable-sourced nitrates had superior benefits compared to synthetic nitrates, Isagenix developed AMPED NOx with a concentrated nitrate-rich vegetable extract including beets, red spinach, and celery.

Additionally, the concentrated shot includes polyphenol-rich fruit extracts. Fruit polyphenols in AMPED NOx function as antioxidants and help support blood flow by assisting in the conversion of nitrates to nitric oxide. These polyphenols not only work well with nitrates, but also support cardiovascular health through their actions on endothelial function (11-13).

References

  1. Van der Avoort CMT, Van Loon LJC, Hopman MTE et al. Increasing vegetable intake to obtain the health promoting and ergogenic effects of dietary nitrate. Eur J Clin Nutr. 2018 Mar 20.
  2. Hall JN, Moore S, Harper SB et al. Global variability in fruit and vegetable consumption. Am J Prev Med. 2009 May;36(5):402-409.e5.
  3. Murphy MM, Barraj LM, Spungen JH et al. Global assessment of select phytonutrient intakes by level of fruit and vegetable consumption. Br J Nutr. 2014 Sep 28;112(6):1004-18.
  4. Van Duyn MA, Pivonka E. Overview of the health benefits of fruit and vegetable consumption for the dietetics professional: selected literature. J Am Diet Assoc. 2000 Dec;100(12):1511-21.
  5. Gangolli SD, van den Brandt PA, Feron VJ et al. Nitrate, nitrite and N-nitroso compounds. Eur J Pharmacol. 1994 Nov 1;292(1):1-38.
  6. Stanaway L, Rutherfurd-Markwick K, Page R et al. Performance and Health Benefits of Dietary Nitrate Supplementation in Older Adults: A Systematic Review. Nutrients. 2017 Oct 27;9(11). pii: E1171.
  7. Jonvik KL, Nyakayiru J, Pinckaers PJ et al. Nitrate-Rich Vegetables Increase Plasma Nitrate and Nitrite Concentrations and Lower Blood Pressure in Healthy Adults. J Nutr. 2016 May;146(5):986-93.
  8. Cooper CE, Giulivi C. Nitric oxide regulation of mitochondrial oxygen consumption II: Molecular mechanism and tissue physiology. Am J Physiol Cell Physiol. 2007 Jun;292(6):C1993-2003.
  9. Dejam A, Hunter CJ, Schechter AN et al. Emerging role of nitrite in human biology. Blood Cells Mol Dis. 2004 May-Jun;32(3):423-9.
  10. Stamler JS, Meissner G. Physiology of nitric oxide in skeletal muscle. Physiol Rev. 2001 Jan;81(1):209-237.
  11. Barona J, Blesso CN, Andersen CJ et al. Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome. Nutrients. 2012 Dec 6; 4(12):1945-57.
  12. Li SH, Tian HB, Zhao HJ et al. The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials. PLoS One. 2013 Jul 24;8(7): e69818.
  13. Ignarro LJ, Byrns RE, Sumi D et al. Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide. Nitric Oxide. 2006 Sep; 15(2):93-102.

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Isagenix Scam? Yes It Is In My Opinion!



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FAQ: Bedtime Belly Buster – Isagenix Health

Whether you’re new to Isagenix or a longtime product user, chances are you’ve heard about the Bedtime Belly Buster (BBB). The BBB is one of our most popular product combinations and can be a great tool to help you break through weight loss plateaus and achieve health and fitness goals.

With the launch of our new BBB bundle, we’ve had a lot of questions come in regarding how the BBB works. That’s why we’ve compiled this FAQ, so you’ll have the answers to your questions about the BBB all in one place!

What Is the Bedtime Belly Buster?

The BBB combines high-quality protein and Isagenix Fruits or Greens to make a “night cap” at the end of your day. Simply blend or mix the core components listed below with any of the optional products you choose and enjoy this satisfying, high-protein treat! The BBB is best when enjoyed 30-60 minutes prior to bed.

The BBB Core Components:

The following complementary products are also commonly taken with the BBB.

BBB Optional Products:

Together, these BBB components are designed to satisfy late-night cravings while helping you get your rest. This, in turn, can help keep you on track to release stubborn belly fat. For more information on how the BBB works to help support your goals, read this article.

If I had a late dinner, should I still do the BBB?

For optimum absorption and utilization of the high-quality whey protein that IsaPro provides, it is best to consume the BBB an hour or two after your last meal. If you enjoyed a late meal rich in protein and this timeline does not fit your schedule, then it may be best to skip your BBB on this occasion. On a Shake Day when you have consumed more calories than planned, it may be best to skip the BBB on these nights as well (if you’re new to Shake Days, see this video here).

Can the BBB be done on a Cleanse Day?

Isagenix does not recommend incorporating the BBB into your Cleanse Day. Remember, a Cleanse Day is based on the science of intermittent fasting. The goal of a Cleanse Day is to consume as little as possible within your own personal limits while receiving nutritional support from Cleanse for Life® and a few select Isagenix products. The BBB would unnecessarily increase your calorie intake and not support the goal of your Cleanse Day. It is best to save your BBB for Shake Days.

Does the BBB replace a meal?

The star product of the BBB is IsaPro – a high-quality whey protein supplement. IsaPro is not a complete meal replacement like IsaLean™ Shake and IsaLean PRO Shake. For this reason, the BBB is not considered a meal and should not be used as a meal replacement. The BBB is simply a nightly addition to your routine and is designed to support your overall weight wellness goals.

Who should do the Bedtime Belly Buster?

Anyone who has hit a weight loss plateau or who is struggling with late-night snacking can benefit from the BBB. When used in conjunction with the Isagenix Weight Wellness System, the BBB can help you stay on track with your weight wellness goals.

Athletes, or those who are working to tone up and build muscle, can also benefit from this late-night dose of whey protein before bed to support muscle recovery and growth. Athletes may even want to increase the BBB serving of IsaPro to two scoops for maximum results. For more information on how athletes can use the BBB, read this article.

Won’t having the BBB right before bed cause weight gain?

Late-night snacking is often pointed to as a cause for weight gain. However, researchers point to the nutritional quality of a bedtime snack as the determining factor in its effect on your waistline. Consider that many people reach for less nutritious options like ice cream and chips to satisfy late-night cravings. Research has shown that consuming a low-calorie, high-protein snack 30-60 minutes before bed may increase metabolic rate and even decrease early morning hunger. For more information on this study, read this article.

How long should the BBB be used?

There is no limit on how long you can keep the BBB in your nightly routine. Supplementing with the targeted nutrition that the BBB provides prior to bedtime can be incorporated into any lifestyle geared toward health and wellness for as long as you desire.

How many scoops of IsaPro should be used?

The BBB was originally intended to help product users break through weight loss plateaus and get rid of those last few stubborn pounds clinging to the belly. With this goal in mind, the BBB was created with one scoop of IsaPro to provide 18 grams of quality protein at a calorie level that can easily fit within a weight loss system. However, for athletes and individuals who are working to build muscle, the research points to added benefit from around a 40-gram serving of whey protein, or two scoops of IsaPro prior to bedtime for added support for muscle protein synthesis and recovery from heavy workouts. You can customize the way you use the BBB to fit your goals by using one or two scoops of IsaPro.

Do I have to include Fruits or Greens in my BBB routine?

While Isagenix Fruits and Greens are part of the core components of the BBB due to their great taste and phytonutrient content, you can always substitute Ionix® Supreme, a sprinkle of AMPED Hydrate, or even additional IsaPro instead. As long as the high-quality protein is consumed 30-60 minutes before bed, the BBB can still be effective in supporting goals.

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Why Creatine Could Help You Beat the Heat

Nowadays, up to 74 percent of athletes are reportedly using creatine because of its well-researched benefits on performance. However, some athletes have concerns about using the supplement in hot or humid environments, as creatine could have a negative effect on hydration. However, new research suggests that creatine could help with thermoregulation and actually support hydration status. Here’s why:

1. Creatine Attracts Water

As an osmotically active substance, creatine attracts water. Because creatine is stored primarily in muscle tissue, supplementation often increases the amount of water muscle cells retain (1). This is a very important when it comes to exercise performance.

2. Increased Fluid Helps With Thermoregulation

It’s well noted in exercise science that changes in total-body water can have profound effects on performance and body-temperature processes, termed “thermoregulation” (2). Previous studies have demonstrated that dehydration impairs aerobic performance, maximal strength, and anaerobic muscular power (3). In hot and humid environmental conditions, increased sweating and core temperature can lead to dehydration and cardiovascular strain (4).

In the average human body, total-body water varies between 45 and 75 percent of body mass (2). This amount is influenced by such factors as muscle and fat mass, fitness level, and glycogen stores (2). Up to 60 percent of total body water resides inside cells. This is called intracellular fluid. The remaining extracellular fluid, outside of the cells, is composed of blood plasma and interstitial fluid (2).

Interestingly, when exercising in hot and humid environments, an increase in intracellular fluid volume can improve thermoregulation. Essentially, the more hydrated your muscles, the better you can control body temperature.

The role that creatine plays is in storing extra water in the muscle cells to transfer into plasma if necessary. The more water in the plasma increases the more fluid in circulation. This can both prevent dehydration and improve thermoregulation by dissipating heat (5). Not surprisingly, creatine has been reported to slow the increases in core temperature during exercise in the heat (6).

3. Supplementation May Support Heat Tolerance

Based on the results of multiple studies, there’s no clinical evidence that creatine supplementation, when taken in recommended dosages, will increase the risk of dehydration and heat illness (7). On the contrary, as an osmotically active substance, creatine supplementation may decrease the risk of heat illness by lowering exercising core body temperature (6).

In addition, performance benefits include maximal strength, vertical jump height, soccer-specific skills, swimming performance, repeated sprint performance, anaerobic running capacity, resistance training volume, and delaying fatigue (7). Now, add supporting athletes with hydration and heat tolerance. This effect alone may be critical for improving performance times in a variety of indoor and outdoor sports alike.

Once again, creatine is found time and time again to be safe and effective (7). Numerous studies have supported the use of creatine as a sports supplement with demonstrated improvements in performance.

References

  1. Mendel RW, Blegen M, Cheatham C et al. Effects of creatine on thermoregulatory responses while exercising in the heat. Nutrition. 2005 Mar;21(3):301-7.
  2. Sawka MN, Burke LM, Eichner ER et al. American College of Sports Medicine position stand. Exercise and fluid replacement. Med Sci Sports Exerc. 2007 Feb;39(2):377-90.
  3. Sobolewski EJ, Thompson BJ, Smith AE et al. The Physiological Effects of Creatine Supplementation on Hydration: A Review. Am J Lifestyle Med. 2011 July; 5(4): 320-27.
  4. González-Alonso J, Mora-Rodríguez R, Below PR et al. Dehydration markedly impairs cardiovascular function in hyperthermic endurance athletes during exercise. J Appl Physiol (1985). 1997 Apr;82(4):1229-36.
  5. Weiss BA, Powers ME. Creatine supplementation does not impair the thermoregulatory response during a bout of exercise in the heat. J Sports Med Phys Fitness. 2006 Dec;46(4):555-63.
  6. Kilduff LP, Georgiades E, James N et al. The effects of creatine supplementation on cardiovascular, metabolic, and thermoregulatory responses during exercise in the heat in endurance-trained humans. Int J Sport Nutr Exerc Metab. 2004 Aug;14(4):443-60.
  7. Kreider RB, Kalman DS, Antonio J et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017 Jun 13;14:18.

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